The argument against everyone with hyperosmolar hyperglycaemic syndrome being given prophylactic treatment dose anticoagulation

Authors

  • Ketan Dhatariya Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospital NHS Foundation Trust, Colney Lane, Norwich, Norfolk, NR4 7UY
  • Philip Weston

DOI:

https://doi.org/10.15277/bjd.2021.314

Author Biography

Ketan Dhatariya, Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospital NHS Foundation Trust, Colney Lane, Norwich, Norfolk, NR4 7UY

Consultant in diabetes, endocrinology and general medicine

References

Wordsworth G, Robinson AH, Ward A, Atkin M. HHS – full or prophylactic anticoagulation? Br J Diabetes 2014;14:64–6. https://doi.org/10.15277/bjdvd.2014.011

Bryk-Wiązania AH, Undas A. Hypofibrinolysis in type 2 diabetes and its clinical implications: from mechanisms to pharmacological modulation. Cardiovasc Diabetol 2021;20:191. https://doi.org/10.1186/s12933-021-01372-w

Tripodi A, Branchi A, Chantarangkul V, et al. Hypercoagulability in patients with type 2 diabetes mellitus detected by a thrombin generation assay. J Thrombosis Thrombolysis 2011;31:165–72. https://doi.org/10.1007/s11239-010-0506-0

Whelton MJ, Walde D, Havard CW. Hyperosmolar non-ketotic diabetic coma: with particular reference to vascular complications. Br Med J 1971;1:85–6. https://doi.org/10.1136/bmj.1.5740.85

Halmos PB, Nelson JK, Lowry RC. Hyperosmolar non-ketoacidotic coma in diabetes. Lancet 1966;287:675–9. https://doi.org/10.1016/s0140-6736(66)91626-6

Petrauskiene V, Falk M, Waernbaum I, Norberg M, Eriksson JW. The risk of venous thromboembolism is markedly elevated in patients with diabetes. Diabetologia 2005;48:1017–21. https://doi.org/10.1007/s00125-005-1715-5

Carr ME. Diabetes mellitus: a hypercoagulable state. J Diabetes Complications 2001;15:44–54. https://doi.org/10.1016/s1056-8727(00)00132-x

Chaudhuri A, Umpierrez GE. Oxidative stress and inflammation in hyperglycemic crises and resolution with insulin: implications for the acute and chronic complications of hyperglycemia. J Diabetes Complications 2012;26:257–8. https://doi.org/10.1016/j.jdiacomp.2012.04.016

Paton RC. Haemostatic changes in diabetic coma. Diabetologia 1981;21:172–7. https://doi.org/10.1007/BF00252650

Keenan CR, Murin S, White RH. High risk for venous thromboembolism in diabetics with hyperosmolar state: comparison with other acute medical illnesses. J Thromb Haemost 2007;5:1185–90. https://doi.org/10.1111/j.1538-7836.2007.02553.x

Scott A, on behalf of the Joint British Diabetes Societies. Management of hyperosmolar hyperglycaemic state in adults with diabetes. Diabet Med 2015;32:714–24. https://doi.org/10.1111/dme.12757

Pasquel FJ, Tsegka K, Wang H, et al. Clinical outcomes in patients with isolated or combined diabetic ketoacidosis and hyperosmolar hyperglycemic state: a retrospective, hospital-based cohort study. Diabetes Care 2020;43:349–57. https://doi.org/10.2337/dc19-1168

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Published

2021-12-17

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