Hyperglycaemia in COVID-19: improving recognition and management in a single centre
DOI:
https://doi.org/10.15277/bjd.2021.324Keywords:
COVID-19, diabetes mellitus, hyperglycaemia, glycaemic control, quality improvementAbstract
Background: Hyperglycaemia is a recognised complication of COVID-19 disease and is associated with increased morbidity and mortality. Effects are noted in individuals with and without diabetes and potentiated by the use of recognised COVID-19 treatments such as corticosteroids. Early glycaemic control in the inpatient with COVID-19 disease impacts significantly on outcomes.
Methods: A three-phase improvement project evaluated the recognition and management of hyperglycaemia in 120 adult inpatients with COVID-19 disease over a 4-month period. A local guideline and a separate acute care ‘bundle’ were implemented to improve performance. The main outcomes of the project were evaluated in a repeated cross- sectional design; assessing the performance of regular capillary blood glucose monitoring and appropriate treatment of hyperglycaemia where indicated.
Results: Prior to intervention, 78.6% of patients had appropriate capillary blood glucose monitoring and no patients were deemed to receive appropriate treatment. Following interventions, 83–100% of patients had appropriate monitoring and 75–100% received appropriate treatment.
Conclusions: In this setting, implementation of a guideline and a care bundle contributed towards improved recognition and management of hyperglycaemia in patients with COVID-19 disease. Future study could assess the impact of interventions on a larger scale whilst investigating variation in the subtype of diabetes, patient sex and other demographics on outcomes such as length of stay, morbidity and mortality.
References
Diabetes UK National Inpatient Diabetes COVID-19 Response Group. COVID: Diabetes. Dexamethasone therapy in COVID-19 patients: implications and guidance for the management of blood glucose in people with and without diabetes. Available from: https://www.diabetes.org.uk/resources-s3/public/2020-06/COvID_Dex_v1.4.pdf (accessed 1 April 2021).
Lim S, Bae JH, Kwon HS, Nauck MA. COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nat Rev Endocrinol 2021;17:11–30. https://doi.org/10.1038/s41574-020-00435-4
Sardu C, D’Onofrio N, Balestrieri ML, et al. Hyperglycaemia on admission to hospital and COVID-19. Diabetologia 2020;63:2486–7. https://doi.org/10.1007/s00125-020-05216-2
Apicella M, Campopiano MC, Mantuano M, et al. COVID-19 in people with diabetes: understanding the reasons for worse outcomes. Lancet Diabetes Endocrinol 2020;8(9):782–92. https://doi.org/10.1016/S2213-8587(20)30238-2
Scheen A. DPP-4 inhibition and COVID-19: from initial concerns to recent expectations. Diabetes Metab 2020;47(2):101213. https://doi.org/10.1016/j.diabet.2020.11.005
Lalau JD, Al-Salameh A, Hadjadj S, et al. Metformin use is associated with a reduced risk of mortality in patients with diabetes hospitalised for COVID-19. Diabetes Metab 2020;47(5):101216. https://doi.org/10.1016/j.diabet.2020.101216
Grasselli G, Zangrillo A, Zanella A, et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-a Admitted to ICUs of the Lombardy Region, Italy. JAMA 2020;323(16):1574–81. https://doi.org/10.1001/jama.2020.5394
Garg S, Kim L, Whitaker M, et al. Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019 – COVID-NET, 14 States, March 1–30, 2020. Centres for Disease Control and Prevention. MMWR 2020;69(15):458–64. https://doi.org/10.15585/mmwr.mm6915e3
Närhi F, Drake T, Harrison E, et al. Delayed adoption of corticosteroids as standard of care for hypoxic patients with COVID-19 in the UK. COVID-19 Clinical Information Network 2020. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/935215/co-cin-delayed-adoption-steroids-covid-19-patients-s0846-291020.pdf (accessed 1 April 2021).
Horby P, Lim WS, Emberson J, et al. Dexamethasone in hospitalized patients with Covid-19. N Engl J Med 2021;384:693–702. https://doi.org/10.1056/NEJMoa2021436
Bode B, Garrett V, Messler J, et al. Glycemic characteristics and clinical outcomes of COVID-19 patients hospitalized in the United States. J Diabetes Sci Technol 2020;14(4):813–21. https://doi.org/10.1177/1932296820924469
Published
Issue
Section
License
Publish & Transfer of Copyright Agreement
For the mutual benefit and protection of the Author and the Journal Owner/Publisher it is necessary that the Author provides formal written Consent to Publish and Transfer of Copyright before publication of the Work.