A case of haemochromatosis and diabetes: a missed opportunity

Authors

  • Hiang Leng Tan Weston General Hospital, Weston-super-Mare, UK
  • Feaz Babwah The County Hospital, Hereford, Wye Valley NHS Trust, UK
  • Muhammad Imran Butt Peterborough City Hospital, Edith Cavell Campus, Bretton Gate, Peterborough, Cambridgeshire, UK
  • Najeeb Waheed The County Hospital, Hereford, Wye Valley NHS Trust, UK

DOI:

https://doi.org/10.15277/bjdvd.2014.038

Abstract

Background

Haemochromatosis is the most common inherited disorder that causes the body to retain excessive amounts of iron.1 It is ten times more common in males and results in iron accumulation in various organs, in particular the liver and pancreas. The prevalence in various northern European populations is estimated to be as high as 1 in 200.

The relationship between haemochromatosis and diabetes mellitus has been well established and documented in medical literature, hence the term ‘bronze diabetes’. Diabetes affects 30% to 60% of patients with hereditary haemochromatosis.2 Although the underlying pathophysiology of diabetes in patients with haemochromatosis has not been fully elucidated, it is thought to be multifactorial.

References

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Dinsmoor RS. Hemochromatosis. 2006 May (cited 2013 June 25). Available from http://www.diabetesselfmanagement.com/Articles/Diabetes-Definitions/hemochromatosis/

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Niederau C, Fischer R, Purschel A, et al. Long-term survival in patients with hereditary hemochromatosis. Gastroenterology 1996;110:1107–19. http://dx.doi.org/10.1053/gast.1996.v110.pm8613000

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McDermott JH, Walsh CH. Hypogonadism in hereditary haemochromatosis. JCEM 2005;90:2451-5.

Feldman HA, Longcope C, Derby C, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study. JCEM 2002; 87:589-98.

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Published

2014-11-24

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Section

Case Reports

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