A case of haemochromatosis and diabetes: a missed opportunity

Hiang Leng Tan, Feaz Babwah, Muhammad Imran Butt, Najeeb Waheed

Abstract


Background

Haemochromatosis is the most common inherited disorder that causes the body to retain excessive amounts of iron.1 It is ten times more common in males and results in iron accumulation in various organs, in particular the liver and pancreas. The prevalence in various northern European populations is estimated to be as high as 1 in 200.

The relationship between haemochromatosis and diabetes mellitus has been well established and documented in medical literature, hence the term ‘bronze diabetes’. Diabetes affects 30% to 60% of patients with hereditary haemochromatosis.2 Although the underlying pathophysiology of diabetes in patients with haemochromatosis has not been fully elucidated, it is thought to be multifactorial.

Full Text:

HTML PDF

References


Wieringa D, Rankin M. Hemochromatosis and diabetes mellitus: the ‘bronze diabetes’. Australian Diabetes Educator 2010;13:4

Hatunic M, Finucane FM, Brennan AM, Norris S, Pacini G, Nolan JJ. Effect of iron overload on glucose metabolism in patients with hereditary hemochromatosis. Metabolism 2010;59:380-4. http://dx.doi.org/10.1016/j.metabol.2009.08.006

Dinsmoor RS. Hemochromatosis. 2006 May (cited 2013 June 25). Available from http://www.diabetesselfmanagement.com/Articles/Diabetes-Definitions/hemochromatosis/

Capell P. Haemochromatosis in type 2 diabetes. Clinical Diabetes 2004; 22:101-02. http://dx.doi.org/10.2337/diaclin.22.2.101

Alert over misdiagnosis of diabetes. 2011 Mar (cited 2013 June 25). Available from http://www.diabetes.co.uk/news/2011/Mar/alert-over-misdiagnosis-of-diabetes-94523038.html

Niederau C, Fischer R, Purschel A, et al. Long-term survival in patients with hereditary hemochromatosis. Gastroenterology 1996;110:1107–19. http://dx.doi.org/10.1053/gast.1996.v110.pm8613000

Fructosamine. 2013 Mar (cited 2013 June 20). Available from http://labtestsonline.org/understanding/analytes/fructosamine/tab/test

GAD antibodies. 2013 Oct (cited 2013 June 27). Available from http://www.diapedia.org/type-1-diabetes-mellitus/gad-antibodies

McDermott JH, Walsh CH. Hypogonadism in hereditary haemochromatosis. JCEM 2005;90:2451-5.

Feldman HA, Longcope C, Derby C, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study. JCEM 2002; 87:589-98.




DOI: https://doi.org/10.15277/bjdvd.2014.038

Refbacks

  • There are currently no refbacks.


The Journal of the Association of British Clinical Diabetologists