GLP-1 receptor agonists in type 2 diabetes - NICE guidelines versus clinical practice

Authors

  • Ken y Thong School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
  • Piya S Gupta Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
  • Melissa L Cull Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
  • Karen A Adamson St John's Hospital, Livingston, UK
  • David S Dove Heatherwood and Wexham Park Hospitals NHS Foundation Trust, Wexham, UK
  • Susannah V Rowles Pennine Acute Hospitals NHS Trust, Greater Manchester, UK
  • Stephanie Tarpey Pennine Acute Hospitals NHS Trust, Greater Manchester, UK
  • Catriona Duncan Victoria Hospital, Kirkcaldy, UK
  • John Chalmers Victoria Hospital, Kirkcaldy, UK
  • Roy Harper The Ulster Hospital, Dundonald, UK
  • Paula Mcdonald The Ulster Hospital, Dundonald, UK
  • Ursula Brennan he Ulster Hospital, Dundonald, UK
  • Chris Walton Hull Royal Infirmary, Hull, UK
  • Robert EJ Ryder Hull Royal Infirmary, Hull, UK

DOI:

https://doi.org/10.15277/bjdvd.2014.015

Abstract

Injectable glucagon-like peptide-1 receptor agonists (GLP-1ras) have the distinct advantage of promoting weight loss as well as lowering glucose in type 2 diabetes. Treatment with a GLP-1ra is costly, thereby necessitating a restriction on widespread use, thus in the UK the National Institute for Health and Care Excellence (NICE) has published guidance on the use of these drugs.

In the UK the Association of British Clinical Diabetologists (ABCD) conducted two nationwide audits on the use of exenatide twice daily and liraglutide once daily and noticed that deviations from NICE guidelines were common. Herein data have been used from both audits (following a combined total of 12,955 type 2 diabetes patients) to evaluate these treatment decisions, critically appraise the NICE guidelines and formulate recommendations for the use of GLP-1ras.

Author Biography

John Chalmers, Victoria Hospital, Kirkcaldy, UK

The Ulster Hospital, Dundonald, UK

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Published

2014-06-09

Issue

Vol. 14 No. 2 (2014)

Section

Learning from practice

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