From muck to molecule: insulin discovery over 50 years


  • Philip Home Newcastle University



diabetes, insulin, discovery


Banting FG, Best CH, Collip JB. Assignment to the governors of the University of Toronto. 1923. ject/insulin%3AQ10013 (accessed 15 May 2022).

Bliss, M. The discovery of insulin. Edinburgh: Paul Harris, 1983. ISBN 13:9780226058979

Langerhans P. Beiträge zur mikroskopischen Anatomie der Bauchspeichel- drüse. Med dissertation. Berlin: G Lange, 1869.

Lancereaux É. Notes et réflexions à propos de deux cas de diabètes sucré avec altération du pancréas. Bull Acad Méd Paris 1877;6:1215–40.

von Mering J, Minkowski O. Diabetes Mellitus nach Pankreasextirpation. Arch Exp Pathol Pharmakol 1890;26:371–87.

Opie EL. The relation of diabetes mellitus to lesions of the pancreas. J Exp Med 1901;5:527–540.

Alberti KGMM, Bailey CFDD. The discovery of insulin. Br J Diabetes 2022; 22(supp1):S3-S5.

Harrison, GA. Insulin in alcoholic solution by the mouth. Br Med J 1923; 2 (Dec 22; 3286):1204–1205.

Abel JJ. Crystalline insulin. Proc Natl Acad Sci (Wash) 1926;12:132–6.

Cameron AT. The chemical nature of insulin. Can Med Assoc J 1928;19: 356–357. PMID 20317014

Lawrence MC. Understanding insulin and its receptor from their three- dimensional structures. Mol Metab 2021;52:101255 10.1016/j.molmet.2021.101255.

Scott DA. Crystalline insulin. Biochem J 1934;28:1592–602. 10.1042/bj0281592

Crowfoot D. X-ray single crystal photographs of insulin. Nature 1935;135: 591–2.

Crowfoot D. The crystal structure of insulin: I. The investigation of air-dried insulin crystals. Proc Roy Soc A 1938;164:580–602. 10.1098/rspa.1938.0038

Crowfoot D, Riley D. X-ray measurements on wet insulin crystals. Nature 1939;144:1011–12.

Crowfoot Hodgkin D. X rays and the structure of insulin. Brit Med J 1971; 4:447–51.

Sanger F. Chemistry of insulin. Br Medical Bull 1960;16:183–8.

Owens DR. Purity and immunogenicity of insulin. In, Owens DR, Human insulin: clinical pharmacological studies in normal man. Lancaster: MTP Press, 1986, 12–18.

Home P. The evolution of insulin therapy. Diabetes Res Clin Pract 2021; 175:108816.

Scott DA, Fisher AM. Studies on insulin with protamine. J Pharmacol Exp Ther 1936;58:78–92.

Hagedorn HC. Protamine insulinate. Proc Roy Soc Med 1937;30:805–13.

Krayenbühl C, Rosenberg T. Crystalline protamine insulinate. Rep Steno Mem Hosp Nord Insulinlab (Copenh) 1946;1:60–73.

Hallas-Møller K, Jersild M, Petersen K, Schlichtkrull J. The lente insulins. Insulin zinc suspensions. Dan Med Bull 1954;1:132–42.

Turner RC, Grayburn JA, Newman GB, Nabarro JDN. Measurement of the insulin delivery rate in man. J Clin Endocr 1971;33:279–86.

Alberti KG, Hockaday TD, Turner RC. Small doses of intramuscular insulin in the treatment of diabetic 'coma'. Lancet 1973;2:515–22. 10.1016/S0140-6736(73)92346-5

DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. J Clin Endocrinol Metab 1979;237:214–23.

Home PD, Shepherd GAA, Noy G et al. Comparison of the activity and pharmacokinetics of porcine insulin and human insulin (NOVO) as assessed by the glucose clamp technique in normal diabetic man. Diabetes Care 1983;6 [suppl 1]: 23–28.

Gardner DF, Arakaki RF, Podet EJ, Nell LJ, Thomas JW, Field JB. The phar- macokinetics of subcutaneous regular insulin in type I diabetic patients: as- sessment using a glucose clamp technique. J Clin Endocrinol Metab 1986; 63:689–94. https:// 10.1210/jcem-63-3-689.