The discovery of insulin

Authors

  • K George MM Alberti Imperial College, London, UK
  • Cliff Bailey Aston University, Birmingham, UK

DOI:

https://doi.org/10.15277/bjd.2022.352

Keywords:

pancreas, extracts, diabetes, insulin, history

References

Bliss M. The discovery of insulin: 25th Anniversary Edition. 2007, University of Toronto Press, Toronto, 2007.

Langerhans P. Beiträge zur mikroscopischen Anatomie der Bauchspeichel- drüse. Inaugural-dissertation. Gustav Lange, Berlin, 1869.

Houssay BA. The discovery of pancreatic diabetes: the role of Oscar Minkowski. Diabetes 1962;1:112-16.

von Mering JV, Minkowski O. Diabetes mellitus nach Pankreasexstirpation. Zentral Klin Medzin 1889;10: 394-5.

Luft R. Oskar Minkowski: discovery of the pancreatic origin of diabetes, 1889. Diabetologia 1989;32:399-401. https://doi.org/10.1007/BF00271257

Nwaneri C. Diabetes mellitus: a complete ancient and modern historical perspective. Webmed Central Diabetes 2015;6:WMC004831. https://doi.org/10.9754/journal.wmc.2015.004831

Tattersall R. Pancreatic organotherapy for diabetes, 1889-1921. Medical History 1995;39:288-316. https://doi.org/10.1017/s0025727300060087

Karamanou M, Protogerou A, Tsoucalas G, Androutsos G, Poulakou-Rebe- lakou E. Milestones in the history of diabetes mellitus: the main contribu- tors. World J Diabetes 2016;7:1–7. https://doi.org/10.4239/wjd.v7.i1.1

Hoet JP. Gustave Edouard Laguesse: his demonstration of the significance of the islands of Langerhans. Diabetes 1953;2:322–4. https://doi.org/10.2337/diab.2.4.322

Opie EL. On the relation of chronic interstitial pancreatitis to the islands of Langerhans and to diabetes mellitus. J Exp Med 1901;5:397–428. https://doi.org/10.1084/jem.5.4.397

Vecchio I, Tornal C, Bragazzi BL, Martini M. The discovery of insulin: an im- portant milestone in the history of medicine. Front Endocrinol (Lausanne) 2018;9:613. https://doi.org/10.3389/fendo.2018.00613

Rennie J, Fraser T. The islets of Langerhans in relation to diabetes. Biochem J 1907;2:7-19. https://doi.org/10.1042/bj0020007

Zuelzer G. Ueber Versuche einer specifischen Fermenttherapie des Diabetes. Zeitschrift für die experimentelle Pathologie und Therapie 1908;

:307–18.

Scott EL. On the influence of intravenous injections of an extract of the pancreas on experimental pancreatic diabetes. Am J Physiol 1912;9:306–310. https://doi.org/10.1152/ajplegacy.1912.29.3.306

Murlin JR, Kramer B. The influence of pancreatic and duodenal extracts on the glycosuria and the respiratory metabolism of depancreatized dogs. J Biol Chem 1913;15:365-83. https://doi.org/10.3181/00379727-10-108

Kleiner I. The action of intravenous injections of pancreas emulsions in ex- perimental diabetes. J Biol Chem 1919;40:153-70.

Banting FG, Best CH. The internal secretion of the pancreas. J Lab Clin Med 1922;7:251–66.

Barron M. The relation of the islets of Langerhans with special reference to cases of pancreatic lithiasis. Surg Gynecol Obstet 1920;31:437–48.

Porta M. One hundred years ago: the dawning of the insulin era. Acta Diabetologica 2021;58:1–4. https://doi.org/10.1007/s00592-020-01642-1

Gley E. Action des extraits de pancréas sclérosé sur des chiens diabétiques (par extirpation du pancréas). C R Seances Soc Biol 1905;2:1322-25.

Paulesco NC. Recherche sur le rôle du pancréas dans l’assimilation nutritive.

Arch Int Physiol 1921;16:85–103.

Meyer J. Action de la sécrétion interne du pancréas sur différents organes et en particulier sur la sécrétion rénale. Arch Fisiol 1909;7:96–9.

Fralick M, Zinman B. The discovery of insulin in Toronto: beginning a 100 year journey of research and clinical achievement. Diabetologia 2021;64: 947–53. https://doi.org/10.1007/s00125-020-05371-6

Downloads

Published

2022-12-22