BJD

Series: Cardiovascular outcome trials for diabetes drugs Semaglutide and SUSTAIN-6

Miles Fisher

Address for correspondence: Professor Miles Fisher
Department of Diabetes, Endocrinology & Clinical Pharmacology, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK
E-mail: miles.fisher@ggc.scot.nhs.uk
https://doi.org/10.15277/bjd.2021.301

Abstract

SUSTAIN-6 (Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes) was a pre-licensing FDA-mandated cardiovascular outcome trial with subcutaneous semaglutide and was the first completed trial with a once-weekly glucagon-like peptide-1 receptor agonist. SUSTAIN-6 compared semaglutide and placebo in 3,297 people with type 2 diabetes and established cardiovascular disease, chronic kidney disease, or both, or who were aged over 60 years and had subclinical evidence of cardiovascular disease (persistent microalbuminuria or proteinuria, hypertension with left ventricular hypertrophy, left ventricular dysfunction by imaging, ankle/brachial index less than 0.9). As SUSTAIN-6 was performed as a pre-licensing safety study, non-inferiority for major cardiovascular events (MACE; cardiovascular death, non-fatal myocardial infarction, non-fatal stroke) was the primary outcome and testing for superiority for MACE was not pre-specified or adjusted for multiplicity. SUSTAIN-6 confirmed non-inferiority for MACE, with nominal superiority, and demonstrated a significant reduction in the risk of non-fatal stroke. There was no significant difference in non-fatal myocardial infarction, cardiovascular death, all-cause mortality or hospitalisation for heart failure. Rates of retinopathy complications were unexpectedly higher in the semaglutide group. Further outcome trials with subcutaneous semaglutide are in progress, including a cardiovascular outcome trial in non-diabetic subjects with overweight or obesity.

Br J Diabetes 2021;21:110-112

Key words: diabetes, cardiovascular outcome trial, semaglutide

Introduction

Licensing requirements for new antidiabetic drugs changed in the USA following the rosiglitazone controversy, and between 2008 and 2020 a dedicated randomised controlled cardiovascular outcome trial (CVOT) was usually required either before or after licensing.1 This series describes and summarises the results of these CVOTs in the order that they were published, describing the primary endpoint and important secondary outcomes from the principal publication, and directs attention to subsequent publications of data from subgroups and post hoc analyses. SUSTAIN-6 was the third published FDA-mandated CVOT using a glucagon-like peptide-1 (GLP-1) receptor agonist, and the first with a once-weekly agonist.2 It came after one negative trial with the short-acting GLP-1 receptor agonist lixisenatide,3 whereas the LEADER trial with liraglutide had demonstrated significant reductions in major adverse cardiovascular events (MACE), cardiovascular deaths and all-cause mortality.4

Background

SUSTAIN-6 was a pre-licensing trial and was completed in 2016. Once-weekly subcutaneous semaglutide was approved in 2017 by the FDA for use in the USA and by the EMA for use in Europe in 2018. Semaglutide was the fourth once-weekly GLP-1 receptor agonist to be approved by the FDA and EMA following approval of once-weekly exenatide, albiglutide and dulaglutide. These three drugs were approved based on cardiovascular safety data from their development programmes, and each was later followed by a dedicated CVOT: exenatide with EXSCEL,5 albiglutide with Harmony Outcomes6 and dulaglutide with REWIND.7

SUSTAIN-6

The principal results from SUSTAIN-6 were presented in 2016 at the meeting of the European Association for the Study of Diabetes and published simultaneously in the New England Journal of Medicine.2 The design of the study and key baseline characteristics of SUSTAIN-6 are described in Box 1.

745 Fisher Box 1

In SUSTAIN-6 there was non-inferiority for MACE, a composite of cardiovascular death, non-fatal myocardial infarction and non-fatal stroke, with semaglutide (Figure 1, Box 2). Testing for superiority for MACE was not pre-specified or adjusted for multiplicity, but MACE was significantly reduced in the semaglutide group. In the semaglutide group there were statistically significant reductions in an expanded composite outcome (MACE, coronary or peripheral revascularisation, hospitalisation for unstable angina or heart failure) and in non-fatal stroke. There were no significant differences in the rates of non-fatal myocardial infarction, cardiovascular death, death from any cause or hospitalisation for heart failure. Rates of new or worsening nephropathy were lower in the semaglutide group. The rate of gastrointestinal events was increased with semaglutide and there was an unexpected increase in retinopathy complications with semaglutide (vitreous haemorrhage, blindness or conditions requiring treatment with an intravitreal agent or photocoagulation).

745 Fisher Figure 1745 Fisher Box 2

Other results from SUSTAIN-6

Further publications from SUSTAIN-6 are detailed in Box 2. To get further information about the effects of semaglutide on diabetic retinopathy, data across the SUSTAIN development programme were evaluated and no imbalance in retinopathy was detected.8 Further analysis of SUSTAIN-6 showed that the majority of the effects were attributed to the magnitude and rapidity of the reduction in HbA1c during the first 16 weeks of treatment in subjects with pre-existing diabetic retinopathy, poor glycaemia control at baseline, and patients treated with insulin.8 The investigators concluded that early worsening of diabetic retinopathy is a previously known phenomenon associated with rapid and large improvements in glycaemic control with insulin, and the findings in SUSTAIN-6 were consistent with this. This ‘early worsening phenomenon’ related to the speed and degree of improvement in glycaemic control has been accepted by Public Health England.9

SUSTAIN-6 was a pre-licensing CVOT with a smaller number of subjects and lower number of events than most other CVOTs. As an example, the LEADER trial with liraglutide included 9,340 subjects and 1,302 MACE events whereas SUSTAIN-6 included 3,297 subjects with only 254 MACE events. This limits statistical power for further analyses, so there are few other publications from SUSTAIN-6 (Box 2). To get round this problem, further analyses have been performed combining data from SUSTAIN-6 and LEADER and SUSTAIN-6 and PIONEER 6 (Box 2).

Discussion

SUSTAIN-6 was the first CVOT with a once-weekly GLP-1 receptor agonist and demonstrated significant cardiovascular benefits with a reduction in MACE and non-fatal stroke, and an unexpected increase in diabetic retinopathy. As for the LEADER trial with liraglutide, the separation of cardiovascular events was later than that observed in studies of sodium-glucose co-transporter-2 (SGLT2) inhibitors, suggesting a different mechanism of benefit and one that might be related to slowing the progression of atherosclerosis.4 There was no imbalance in diabetic retinopathy comparing oral semaglutide and placebo in the pre-licensing PIONEER 6 CVOT.10 Further information on the effects of subcutaneous semaglutide on the progression of diabetic kidney disease retinopathy will be available from the FLOW renal outcome trial,11 and further information effects of subcutaneous semaglutide on the progression of diabetic retinopathy will be available from the FOCUS study.12 At present, semaglutide is probably best avoided in patients with significant diabetic retinopathy and liraglutide or dulaglutide are alternatives that have not been associated with worsening of retinopathy. Additional information on the effects of subcutaneous semaglutide on cardiovascular events is being studied in approximately 17,500 overweight and obese subjects in the SELECT trial, with an estimated completion date of September 2023.13

745 Fisher Key Messages

Conflict of interest The author has received payment for advisory boards and/or lectures from Allergan, AstraZeneca, Bayer, Boehringer Ingelheim, Daiichi, Eli Lilly, Lexicon, MSD, NAPP, Novo Nordisk and Sanofi.

Funding None.

References

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