BJD

Diabetic ketoacidosis in people on maintenance haemodialysis: case reports and review of literature

Apexa Kuverji,1 Kath Higgins,2 James O Burton,3 Andrew H Frankel,4 Chee Kay Cheung5

1 Specialist Registrar in Nephrology and General Internal Medicine, John Walls Renal Unit, Leicester General Hospital, Leicester, UK
2 Lead Clinician for Inpatient Diabetes Care and Consultant in Diabetes Care, Honorary Senior Lecturer University of Leicester, Leicester Diabetes Centre, Leicester General Hospital, Leicester, UK
3 Professor of Renal Medicine, Honorary Consultant Nephrologist, John Walls Renal Unit, Leicester General Hospital, Leicester, UK
4 Consultant Physician and Nephrologist, Imperial College Healthcare NHS Trust, London; Lead for Diabetes Care in Haemodialysis Working Group, UK
5 NIHR Academic Clinical Lecturer and Consultant Nephrologist,
  University of Leicester, John Walls Renal Unit, Leicester General Hospital, Leicester, UK

Address for correspondence: Dr Apexa Kuverji
Specialist Registrar in Nephrology and General Internal Medicine, John Walls Renal Unit, Leicester General Hospital, Leicester, UK
E-mail: apexa.kuverji@uhl-tr.nhs.uk

https://doi.org/10.15277/bjd.2020.253

Abstract

The management of diabetes ketoacidosis (DKA) in people with normal renal function is well established. Although DKA is less common in people with end-stage kidney disease (ESKD), when it occurs, the management needs to be adapted to account for the different physiological state that these patients present with. This report presents two cases of DKA in people on maintenance haemodialysis for ESKD. Each case identifies learning points, when combined with a comprehensive literature review, generates key recommendations on the management of DKA in people on maintenance haemodialysis.

Br J Diabetes 2020:ONLINE AHEAD OF PUBLICATION

Key words: diabetic ketoacidosis, haemodialysis, end-stage kidney disease

Introduction

Diabetic ketoacidosis (DKA) is less common in people with end-stage kidney disease (ESKD) than in those with normal renal function. Deteriorating renal function offsets poor glycaemic control by a reduction in gluconeogenesis, changes in insulin catabolism and a reduction in insulin clearance.1 Osmotic diuresis rarely occurs in patients with oligo-anuric ESKD, consequently protecting them from dehydration. Regular haemodialysis also reduces risks of severe metabolic acidosis. When DKA does occur in people on maintenance haemodialysis, the treatment can be challenging and many of the protocolised management guidelines defined for patients with normal kidney function do not apply. We present two case reports of DKA occurring in people on maintenance haemodialysis and a review of the literature with recommendations for management.

Case 1

A 42-year-old male with a background of ESKD on haemodialysis for 3 years presented with vomiting for 12 hours. He was diagnosed with type 2 diabetes mellitus 10 years previously, and had started on insulin therapy within 4 months of diagnosis. His glucose control had always been poor with HbA1c rarely below 64 mmol/mol and reaching 190 mmol/mol. He had previously had three admissions for DKA since starting haemodialysis. He had undergone haemodialysis the day before admission, after which he felt clammy, nauseated and lethargic. The following morning his carer had noticed that he looked unwell and called the paramedics, who tested his capillary blood glucose (CBG) and found this to be 26 mmol/L. His heart rate was 108 beats/min and blood pressure was 130/51 mmHg.

On arrival at the emergency department (ED) his Glasgow Coma Score (GCS) was 15/15 and he was clinically euvolaemic. His blood tests are shown in Table 1. He was diagnosed with DKA and treatment was initiated.

555 Kuverji Table 1

He was started on an intravenous infusion of 0.9% sodium chloride with 40 mmol/L potassium chloride within 30 min of presentation to ED. This infusion ran for 1 h but was changed to 0.9% sodium chloride only, after the repeat potassium result came back at 5.0 mmol/L. This infusion ran slowly at 100 mL/h.

His weight was 77 kg. He was started on a fixed rate intravenous insulin infusion (FRIII) at 0.1 unit/kg/h and then changed to a variable rate intravenous insulin infusion (VRIII) after 3 h as his DKA had resolved. The initial pH of 7.29 suggests that the DKA was borderline. The resolution of DKA within 3 h supports this diagnosis. The VRII infusion continued until transfer to the renal ward 11 h later. He was prescribed his regular Novomix30® subcutaneous insulin for the following morning and VRIII was stopped the next day, with regular point-of-care testing of his CBG and ketones. He was dialysed the following afternoon as per his usual schedule. He was reviewed 3 days later by the diabetes team for his subcutaneous insulin dosing.

Case 2

A 34-year-old female with a background of type 1 diabetes mellitus, left ventricular systolic dysfunction and ESKD secondary to diabetic nephropathy presented directly to the renal department with vomiting. She had missed a session of haemodialysis and had last dialysed 4 days previously. She had felt well on the previous day, but was drowsy on presentation and had been vomiting for the past 12 hours. More recently the vomitus was coffee-ground in nature.

Her blood pressure was 140/83 mmHg, heart rate was 98 beats/min and oxygen saturations were 98% on room air. Her GCS was 10/15 (E1, M6, V3) and no focal neurological deficit was identified. She was clinically euvolaemic, with moist mucus membranes, no evidence of pulmonary oedema and had longstanding anuria. Her Permcath (tunnelled dialysis catheter) was clean at the exit site. Her target weight was 59.7kg, but there was no weight available on admission due to her clinical condition. Her blood tests are shown in Table 2. She was transferred from the ward to the renal High Dependency Unit for cardiac monitoring and, in view of her level of acidosis and low GCS, the Intensive Care Unit (ICU) team was informed. ECG showed widespread tented T waves and no other abnormalities. Due to the anticipated time taken to start dialysis, an intravenous. insulin-dextrose infusion was given as per local protocol for hyperkalaemia. She was started on a FRIII of 8 units/h, and the plan was to dialyse for 4 h with a low pump speed to ameliorate the risk of haemodynamic instability or rapid reductions in plasma osmolality. In view of the coffee-ground vomiting, low molecular weight heparin was withheld and intravenous omeprazole was prescribed.

555 Kuverji Table 2

When attempting to start haemodialysis, the patient’s Permcath (which had been exchanged 10 days previously) did not aspirate well and could not be used. An alteplase lock was unsuccessful, so a urokinase infusion (25,000 units per lumen) was given over 3 h, which successfully unblocked the catheter. The patient had central venous stenosis and occlusions from previous venous access, resulting in difficulty in gaining alternative vascular access. A second peripheral venous cannula could not be placed despite multiple attempts.

At 4 h, when repeat blood tests showed improving acidosis and hyperglycaemia but an increase in ketones, the FRIII was increased to 9 units/h. Approximately 12 h after the initial presentation, the patient was started on haemodialysis. CBG levels were closely monitored during haemodialysis for hypo- glycaemia. Hypoglycaemia would have to be treated by stop-ping haemodialysis and giving intravenous dextrose via the Permcath.

Once 4 h of haemodialysis was completed, the patient was started on 125 mL/h 10% dextrose as her CBG was 6.0 mmol/L. By the following morning her DKA had resolved (ketones 0.6 mmol/L, CBG 8.3 mmol/L) and her GCS recovered. The FRIII was reduced from 8 units/h to 6 units/h until midday, when her CBG dropped to 3.3, at which point the FRIII was stopped, VRIII was commenced and intravenous 10% dextrose continued.

She was kept on a reduced dose VRIII and intravenous dextrose 10% for 48 h due to anorexia and episodes of hypoglycaemia, with alternate-day haemodialysis to remove excess fluid. She continued to receive her long-acting insulin (Levemir®) at the same dose she was on prior to admission. She remained in hospital for a total of 10 days and was also treated with intravenous vancomycin for line sepsis. Blood cultures taken from the line 6 days prior to admission had grown Staphylococcus aureus, and C-reactive protein on admission was 94 mg/L.

Discussion

These two cases illustrate how the management of DKA in a patient with ESKD on maintenance haemodialysis is complex and multifactorial. Joint British Diabetes Society (JBDS) and American Diabetes Association (ADA) guidelines for the management of DKA in adults suggest that “special attention and caution” needs to be paid to those with kidney failure when it comes to fluid balance and potassium replacement. However, there is no further detail regarding the potential problems and nuances of managing this condition in this particular group of patients.2

Review: methodology and search strategy

We carried out a literature search of articles published in PubMed. The electronic search strategy on 22 October 2019 was as follows: disease (DKA OR Diabetic ketoacidosis OR ketoacidosis) AND association (haemodialysis OR dialysis). A total of 136 papers were identified, of which 122 were excluded by title and abstract evaluation as they were deemed irrelevant. This left 14 papers for analysis, shown in Table 3. Five case reports, five observational studies, one meta-analysis of observational studies and three literature reviews were analysed.3–16

555 Kuverji Table 3a
555 Kuverji Table 3b 555 Kuverji Table 3c

Although six of these articles focused on the management of dialysis-associated hyperglycaemia (with some patients presenting with ketoacidosis), some key themes have emerged that should be considered when managing DKA in this group of patients.

Hyperglycaemia versus risk of adverse glucose events (how much insulin?)

In patients with ESKD, delayed insulin clearance can increase the risk of hypoglycaemia, and therefore the titration of insulin infusion can be complicated.1 Schaapveld-Davis et al found that there was a significantly increased risk of adverse glucose events (hypoglycaemia <4.0 mmol/L or rate of reduction of glucose >11.1 mmol/L/h) in patients with ESKD who presented with DKA compared with a control group of those with an estimated glomerular filtration rate ≥60 mL/min/1.73m2 (33/44 (75%) vs 16/44 (36%), p<0.0001). A similar number of patients in both groups received a bolus of insulin before the insulin infusion was started (93.2% in ESKD group vs 81.8% in controls, p=0.2). However, the ESKD group received a higher cumulative bolus dose of insulin, independent of potassium levels at diagnosis.8

The ADA consensus recommends a rate of reduction of glucose by 50–70 mg/dL/h (equating to 2.8–3.9 mmol/L/h), and although this is aimed at all adults (and not specifically those with ESKD), it is much lower than the previous recommendations from Tzamaloukas et al for dialysis-associated hyperglycaemia of 5.9–6.9 mmol/L/h.15–17 The JBDS guideline recommends a target reduction of CBG by 3.0 mmol/L/h in all adults with DKA.2 The review by Seddik et al,9 which focused on DKA specifically in people with ESKD, recommends a rate of reduction of glucose of 2.8–3.3 mmol/L/h and suggests starting an insulin infusion at a lower dose of 0.05–0.07 units/kg/h to achieve this.

When dosing insulin, another factor to consider is that glucose homeostasis and insulin resistance change with haemodialysis. In non-diabetic adults on MHDx, uraemia-induced insulin resistance improved resulting in better glucose metabolism after haemodialysis.18 Interstitial glucose significantly decreases during haemodialysis, with the nadir at the 3-hour point, and then increases post-dialysis.19 Adjustment of insulin infusion during haemodialysis and the period after should be considered to reduce the extreme variability in glycaemic control and risk of hypoglycaemia. This is considered standard practice for those who are sensitive to insulin or at risk of hypoglycaemia.

As described in Case 2, starting insulin at 0.1 units/kg/h did not adequately resolve the ketoacidosis and increasing the infusion to 0.15 units/kg/h improved the ketoacidosis but resulted in persistent hypoglycaemic episodes in the subsequent days. This was complicated by anorexia, limited vascular access and inability to infuse intravenous glucose to treat hypoglycaemia whilst on haemodialysis. Reflecting on this case, a lower dose of the patient’s long-acting insulin or starting the FRII at a lower dose of 0.05–0.07 units/kg/h may have helped to reduce adverse glucose events. However, the risks of slowing resolution of ketoacidosis must be weighed against risks of hypoglycaemia when deciding on the rate of insulin infusion. Furthermore, the FRII carried on for 4 h longer than was required. Although the diabetes team reviewed the patient later in the admission for her insulin management, involving the diabetes team earlier in this patient’s care may have helped identify and reduce the risks of hypoglycaemia.

The messages from Case 2 highlight the increased risk of hypoglycaemia and the need for consideration of reduction of the rate of insulin infusion to mitigate this risk. It is important to consider the timing of haemodialysis as dialysis is associated with a change in insulin resistance and glucose homeostasis. Once the DKA is resolved, we recommend switching from FRIII to a reduced dose-adjusted VRIII to be given until anorexia is resolved.

Risk of hypokalaemia versus hyperkalaemia

People with ESKD are at a higher risk of hyperkalaemia. An observational study by Tzamaloukas et al13 reported higher initial serum potassium levels in MHDx patients (6.1±1.3 mmol/L) compared with patients on peritoneal dialysis who presented in DKA (5.0±1.0 mmol/L; p=0.006). The frequency of hyperkalaemia was also higher in DKA than in non-ketotic hyperglycaemia.13,15,16 Current JBDS DKA guidelines suggest adding 40 mmol potassium chloride to 0.9% sodium chloride infusion if the potassium falls between 3.5 and 5.5 mmol/L ‘and the patient is passing urine’.2

An observational study of patients on renal replacement therapy who developed hyperglycaemia found that hyperkalaemia in this setting often resolves with insulin infusion alone, and haemodialysis may be reserved for cases of severe hyperkalaemia with the presence of ECG changes.11 Only two out of nine episodes of DKA required potassium replacement, and these cases were due to protracted vomiting prior to presentation.

As people on MHDx are frequently anuric, routine potassium replacement should be avoided in this population. In Case 1 the serum potassium concentration at presentation was normal and remained within normal limits throughout insulin therapy, confirming the physiological understanding that there is an increase in total body stores of potassium due to ESKD.

In Case 2, where hyperkalaemia with ECG changes was present, the literature suggests emergency haemodialysis.5,9,14 If there is potential for delay in achieving this, we suggest small boluses of intravenous insulin as per local hyperkalaemia management guidelines. In this case, 10 units of insulin Actrapid® in 50 mL 50% glucose was administered intravenously as the immediate treatment for hyperkalaemia. This is likely to have contributed to the worsening hyperglycaemia in the first hour of treatment.

We suggest careful monitoring of potassium in people on MHDx and to consider replacement with potassium chloride only if potassium levels are below 3.5 mmol/L and acidosis has been corrected.4,9 Serum potassium levels should be re-checked after administration of potassium chloride. In specific cases of hyperkalaemia in DKA in a person with ESKD where the person is awaiting haemodialysis, the medical management of hyperkalaemia may need to be adapted. When insulin is administered to correct the hyperkalaemia, we suggest that the addition of 50% glucose/dextrose may not be required unless the CBG is less than 14 mmol/L. Dialysis is recommended if hyperkalaemia is severe and associated with ECG changes.

Hypertonicity and fluid balance

DKA and hyperosmolar hyperglycaemic state are often considered as separate entities within management guidelines; however, there is often overlap in the clinical and biochemical picture. Umpierrez et al estimate that approximately 20–30% of patients presenting with hyperosmolar hyperglycaemic state have concomitant ketoacidosis.20 The presence of hyperosmolality is common in DKA, occurring in up to 37% of laboratory findings,17 and has been considered significant in grading the severity of DKA in all adults.21

There are concerns regarding rapid reduction in tonicity in people with DKA being associated with cerebral oedema and pontine myelinosis.5,9,10 The recommended rate of reduction of tonicity (<3 mOsm/kg/h) based on non-ketotic hyperglycaemic crisis is not specific to those with renal failure.17

A meta-analysis of observational studies conducted by Tzamaloukas et al in 2008 found that serum tonicity was lower in the dialysis group than in those with preserved renal function. They suggested that, when hyperglycaemia contributes to increased extracellular tonicity, the fluid shift increases extracellular fluid volume. When DKA occurs in people with preserved renal function, this results in osmotic diuresis and net loss of water, which increases extracellular tonicity. In people on MHDx there is no osmotic diuresis, resulting in increased extracellular volume and reduced extracellular tonicity compared with those without renal failure.14 A reduction of hypertonicity in dialysis-associated hyperglycaemia is seen with insulin therapy alone and aggressive fluid resuscitation is rarely required. We recommend careful assessment of fluid volume status and small boluses (250 mL) of intravenous fluids if deemed hypovolaemic, with frequent re-assessment to avoid fluid overload. This assessment may be complicated if the patient has DKA associated with sepsis. Invasive monitoring and vasopressor support in a critical care setting may be required to optimise intravascular volume status in complex sepsis cases.

Haemodialysis

During haemodialysis, lower glucose dialysates may influence glucose control and increase the risk of hypoglycaemia due to movement of glucose down a concentration gradient.22 There are also concerns that haemodialysis may cause a rapid reduction in hypertonicity in DKA, which could potentially lead to adverse neurological outcomes. In one case report by Gupta et al,5 haemodialysis caused a rapid reduction in tonicity (14.5 mOsm/kg/h) and was stopped 1.5 h after initiation due to fears that this is approximately five times faster than the recommendation.

Another complication that should be considered with haemodialysis, especially in patients who have reduced GCS at presentation or have missed sessions of dialysis, is Dialysis Disequilibrium Syndrome (DDS). The pathophysiology of DDS is unclear, but it is proposed that there is a reverse osmotic shift due to rapid removal of small solutes such as urea, which causes cerebral oedema.23 Risk factors for developing DDS include a high serum urea level >60 mmol/L, first haemodialysis session, extremes of age, pre-existing neurological disease or concomitant disorders associated with cerebral oedema.24 There are no case reports of DDS occurring in the presence of DKA. However, given that DKA may present with reduced GCS, it is an important differential diagnosis to consider.

In Case 1, haemodialysis was not required at the time of presentation and was given on the patient’s normal dialysis day with no complications. He also had no risk factors for developing DDS. In Case 2 there was a delay in starting haemodialysis due to problems with vascular access, and she was at risk of DDS (having presented with low GCS). In order to reduce this risk, we initiated slower pump speed haemodialysis at 180 mL/min blood flow and frequently monitored her GCS throughout the session.

We suggest careful monitoring of CBG during and after haemodialysis due to the increased risk of hypoglycaemia. Studies suggest that emergency haemodialysis should be considered in the event of severe hyperkalaemia with ECG changes or severe refractory pulmonary oedema.5,9,14 In cases where hyperkalaemia is not a complicating factor, isolated ultrafiltration may be used for fluid removal in the event of pulmonary oedema if there is a risk of rapid reduction in tonicity or DDS.

Identify underlying cause

It is important to identify any precipitating causes of DKA, such as missed doses of insulin or underlying infection.5,6,9 In Case 2 the DKA episode was attributed to a Staphylococcus aureus line infection, with the level of acidosis thought to be exacerbated by a missed haemodialysis session. Had the patient’s GCS not recovered despite resolution of DKA, further neurological investigations would have been warranted.

Conclusion

People who present with DKA and have ESKD can be critically ill and management needs to be tailored in response to each individual patient. It is important to understand that DKA can occur in both type 1 and type 2 diabetes, as the risks in type 2 diabetes may not be fully appreciated by non-specialists who may not see this very frequently. Suggestions and recommendations for management are based on very limited evidence in the form of case reports and observational studies only. There are no randomised controlled trials to guide patient care.

Key recommendations on the medical management of DKA in ESKD, based on this literature review, are highlighted in the box above.

It is important to involve specialists such as nephrologists, diabetologists and critical care early. Due to the complex care needs of the patients, there should be a low threshold to escalate to a critical care setting.

555 Kuverji Key Messages

Conflict of interest KH is a member of the Joint British Diabetes Societies Inpatient Group. JOB reports personal fees from NAPP outside the submitted work. The other authors report no conflicts of interest.

Funding None.

Informed consent Written informed consent was obtained from the patient (Case 1) and next of kin (Case 2) for publication of this case report.

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