Diabetes medications with cardiovascular protection – what now after LEADER®? Could metformin, pioglitazone, empagliflozin and liraglutide complement each other to save lives?
DOI:
https://doi.org/10.15277/bjd.2016.096References
Ryder REJ, DeFronzo RA. Diabetes medications with cardiovascular protection in the wake of EMPA-REG OUTCOME™: the optimal combination may be metformin, pioglitazone and empagliflozin. Br J Diabetes Vasc Dis 2015;15:151–4. http://dx.doi.org/10.15277/bjdvd.2015.045
UK Prospective Diabetes Study Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998;352:854–65. http://dx.doi.org/10.1016/S0140-6736(98)07037-8
Dormandy JA, Charbonnel B, Eckland DJ, et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 2005;366:1279–89. http://dx.doi.org/10.1016/S0140-6736(05)67528-9
EASD Virtual Meeting. Webcast: Results of the EMPA-REG OUTCOME™ study. http://www.easdvirtualmeeting.org/contentsessions/2030 (accessed 7 July 2016)
Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 2015;373:2117–28. http://dx.doi.org/10.1056/NEJMoa1504720
ADA 76th Scientific Sessions Webcasts. Results of the Liraglutide Effect and Action in Diabetes-Evaluation of Cardiovascular Outcome Results (LEADER®) trial. http://professional.diabetes.org/search/site?f[0]=im_ field_dbp_ct%3A7&f[1]=sm_field_wcast_mname%3Anode%3A120&f[2]=sm_field_wcast_sname%3Anode%3A144635&retain-filters=1 (accessed 8 July 2016)
Marso SP, Daniels GH, Brown-Frandsen K, et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med 2016;375:311–22. http://dx.doi.org/10.1056/NEJMoa1603827
Abdul-Ghani MA, Del Prato S, Chilton R, DeFronzo RA. SGLT2 inhibitors and cardiovascular risk: lessons learned from the EMPA-REG OUTCOME study. Diabetes Care 2016;39:717–25. http://www.ncbi.nlm.nih.gov/pubmed/27208375. http://dx.doi.org/10.2337/dc16-0041
Ferrannini E, Mark M, Mayoux E. CV Protection in the EMPA-REG OUTCOME trial: a “thrifty substrate” hypothesis. Diabetes Care 2016;39:1108–14. http://www.ncbi.nlm.nih.gov/pubmed/27289126. http://dx.doi.org/10.2337/dc16-0330
Published
Issue
Section
License
Publish & Transfer of Copyright Agreement
For the mutual benefit and protection of the Author and the Journal Owner/Publisher it is necessary that the Author provides formal written Consent to Publish and Transfer of Copyright before publication of the Work.
