Is lasting remission feasible in the real-world setting? Yes!
This article summarises a debate at the 59th EASD Annual Meeting 2-6 October 2023, Hamburg, Germany at which Professor Taylor spoke for the motion and Professor Khunti spoke against the motion
DOI:
https://doi.org/10.15277/bjd.2024.450Keywords:
pathophysiology, weight loss, type 2 diabetesReferences
Taylor R. Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause. Diabetologia 2008;51:1781-9. https://doi.org/10.1007/s00125-008-1116-7
Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 2011;54:2506-14.https://doi.org/10.1007/s00125-011-2204-7
Steven S, Hollingsworth KG, Al-Mrabeh A, et al. Very low-calorie diet and 6 months of weight stability in type 2 diabetes: pathophysiological changes in responders and nonresponders. Diabetes Care 2016;39(5):808-15. https://doi.org/10.2337/dc15-1942
Lean MEJ, Leslie WS, Barnes AC, et al. Durability of a primary care- led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster- randomised trial. Lancet Diabetes Endocrinol 2019;7(5):344-55. https://doi.org/10.1016/S2213-8587(19)30068-3
Taylor R, Al-Mrabeh A, Sattar N. Understanding the mechanisms of reversal of type 2 diabetes. Lancet Diabetes Endocrinol 2019; 7(9):726-36. https://doi.org/10.1016/S2213-8587(19)30076-2
Lean MEJ, Leslie WS, Barnes AC, et al. Five-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT): Extension study of continued support for weight loss maintenance. Lancet Diabetes Endocrinol 2024;12:233-46. https://doi.org/10.1016/S2213-8587(23)00385-6
Taylor R, Barnes AC, Hollingsworth KG, et al. Aetiology of type 2 diabetes in people with a 'normal' body mass index: testing the personal fat threshold hypothesis. Clin Sci (Lond) 2023;137(16):1333-46. https://doi.org/10.1042/CS20230586
Bull CJ, Hazelwood E, Legge DN, et al. Impact of weight loss on cancer-related proteins in serum: results from a cluster randomised- controlled trial of individuals with type 2 diabetes. eBioMedicine 2024;100:104977. https://doi.org/10.1016/j.ebiom.2024.104977
Greenhaugh S. Making China safe for Coke: how Coca-Cola shaped obesity science and policy in China. Brit Med J 2019;364:k5050. https://doi.org/10.1136/bmj.k5050
Peters C, Steven S, Taylor R. Reversal of type 2 diabetes by weight loss despite presence of macro-and micro-vascular complications. In: Draznin B, editor. Diabetes case studies: real problems, practical solutions. Alexandria, VA: American Diabetes Association; 2015.
Whitington J. Fixing Dad. Short Books 2017, pp 223.
Gregg EW, Chen H, Bancks MP, et al. Impact of remission from type 2 diabetes on long-term health outcomes: findings from the Look AHEAD study. Diabetologia 2024;67:459-69 https://doi.org/10.1007/s00125-023-06048-6
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